1 MCQs in Pediatrics for NEET PG
A 7-year-old boy presents with polyuria (4.5 L/day), polydipsia, and nocturia for 3 weeks. MRI brain with contrast shows a thickened (4 mm), enhancing pituitary stalk marked **A** in the diagram, with loss of the normal posterior pituitary bright spot on T1. Water deprivation test shows dilute urine (osmolality 280 mOsm/kg) despite serum osmolality of 305 mOsm/kg. Urine osmolality rises to 620 mOsm/kg after desmopressin administration. A skin biopsy reveals CD1a+/CD207+ cells with Birbeck granules. Which of the following best explains the pathophysiology of central diabetes insipidus in this patient?
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