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    SubjectsPediatricsTuberous Sclerosis with Vigabatrin-Responsive Spasms
    ClinicalPediatrics

    Tuberous Sclerosis with Vigabatrin-Responsive Spasms

    1 MCQs in Pediatrics for NEET PG

    1 Medium
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    A 5-month-old girl presents with clusters of epileptic spasms on awakening. Examination reveals multiple ash-leaf spots and a shagreen patch. Cardiac echo shows rhabdomyomas, and renal ultrasound shows bilateral angiomyolipomas. MRI brain demonstrates cortical tubers, subependymal nodules, and a small SEGA. The EEG pattern marked **A** in the diagram shows a modified hypsarrhythmia with multifocal spikes and preserved interhemispheric synchrony, more prominent over one hemisphere. Genetic testing confirms TSC2 mutation. What is the first-line antiepileptic drug for this patient's infantile spasms?

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