Acute Inflammation

Regarding the cardinal signs and mediators of acute inflammation, all of the following are correct EXCEPT:

Which of the following is the primary mechanism by which histamine causes increased vascular permeability in acute inflammation?

Which of the following complement fragments is the most potent chemotactic agent and primary driver of neutrophil recruitment in acute inflammation?

A 32-year-old male presents to the emergency department with acute onset of severe right lower abdominal pain, fever (38.5°C), and vomiting for 6 hours. On examination, he has localized tenderness at McBurney's point with guarding and rebound tenderness. Blood investigations show WBC 14,500/μL with left shift (80% neutrophils). Ultrasound confirms acute appendicitis. During emergency appendectomy, the surgeon notes the appendiceal wall is hyperemic, edematous, and infiltrated with purulent exudate. Histopathology shows neutrophilic infiltration with fibrin deposition and tissue destruction. Which of the following mediators is MOST responsible for the vascular permeability increase and neutrophil recruitment observed in this acute inflammatory response?

A 32-year-old woman presents with acute suppurative infection of the breast (acute mastitis) with localized abscess formation. She is febrile (38.5°C) and has purulent discharge. Culture is pending. What is the drug of choice for empiric treatment?