Alcoholic Liver Disease

A 48-year-old man with alcoholic hepatitis (AST 320 U/L, ALT 180 U/L, bilirubin 5.8 mg/dL, INR 1.9) and a Maddrey discriminant function score of 68 is admitted for management. He denies variceal bleeding or encephalopathy. Which is the drug of choice for reducing mortality in severe alcoholic hepatitis?

In the progression of alcoholic liver disease, which stage is characterized by reversible hepatic steatosis without significant inflammation or fibrosis?

A 52-year-old man from Delhi presents with a 6-month history of progressive abdominal distension, ankle swelling, and easy bruising. He reports consuming 80–100 g of alcohol daily for the past 15 years. On examination, he has jaundice, spider angiomas on the chest, palmar erythema, and a firm, enlarged liver edge 4 cm below the costal margin. Ascites is present. Laboratory findings: AST 280 U/L, ALT 95 U/L, ALP 210 U/L, bilirubin 4.2 mg/dL, albumin 2.8 g/dL, INR 2.1. Abdominal ultrasound shows cirrhotic echotexture with portal vein diameter 15 mm. What is the most likely histopathological finding in this patient's liver?

A 48-year-old woman from Mumbai with a 12-year history of heavy alcohol consumption (60–80 g/day) presents with acute onset of fever, right upper quadrant pain, and jaundice. She denies recent viral prodrome. Laboratory findings: WBC 14,500/μL, AST 520 U/L, ALT 180 U/L, ALP 320 U/L, bilirubin 6.8 mg/dL, albumin 2.9 g/dL, INR 1.8, prothrombin time 18 seconds. Serum markers for hepatitis A, B, and C are negative. Abdominal ultrasound shows hepatomegaly with coarse echotexture and ascites. A liver biopsy is performed. Which of the following histological findings would be most specific for the acute exacerbation of her underlying chronic alcoholic liver disease?

A 48-year-old Indian man with chronic alcohol abuse presents with hepatomegaly and jaundice. Liver biopsy shows hepatocyte steatosis, inflammation, and characteristic cytoplasmic inclusions. What is the most common histologic finding in alcoholic liver disease?