Chronic Leukemias

Which chromosomal abnormality is the hallmark of chronic myeloid leukemia and results from a reciprocal translocation between chromosomes 9 and 22?

Which cytogenetic abnormality in chronic lymphocytic leukemia is associated with the most favorable prognosis and is detected by fluorescence in situ hybridization (FISH)?

In chronic lymphocytic leukemia, which immunophenotypic marker combination is most characteristic: CD5+, CD19+, CD23+, and surface immunoglobulin expression?

A 55-year-old man is diagnosed with chronic myelomonocytic leukemia (CMML) with 8% blasts in bone marrow and monosomy 7 cytogenetics. He is transfusion-dependent and symptomatic. Which agent is the preferred first-line treatment?

A 62-year-old woman with a 6-year history of chronic lymphocytic leukemia (CLL) presents with progressive lymphadenopathy and anemia (Hb 8.5 g/dL). Flow cytometry confirms CD5+, CD19+, CD23+ B-cell CLL. She is FISH-negative for del(17p) and TP53 mutation. What is the preferred first-line treatment for symptomatic CLL?