Hemolytic Anemias

Which laboratory finding best distinguishes G6PD deficiency from autoimmune hemolytic anemia (AIHA)?

A 28-year-old woman of Mediterranean descent presents with hemolytic anemia, splenomegaly, and a history of gallstones. Which finding best distinguishes β-thalassemia major from hereditary spherocytosis?

In G6PD deficiency, hemolysis is typically triggered by which of the following mechanisms?

A 28-year-old woman presents with jaundice, dark urine, and pallor. Laboratory investigations reveal hemoglobin 8.2 g/dL, reticulocyte count 12%, elevated indirect bilirubin, elevated LDH, and low haptoglobin. Flow cytometry shows absence of CD55 and CD59 on blood cells. What is the drug of choice for acute hemolytic episodes in this patient?

A 42-year-old woman with a 3-year history of jaundice, splenomegaly, and recurrent hemolytic episodes presents with acute hemolysis (hemoglobin 7.8 g/dL, reticulocyte count 16%, elevated indirect bilirubin, elevated LDH). Direct antiglobulin test (DAT/Coombs) is strongly positive with IgG and C3 coating. What is the drug of choice for acute hemolytic episodes in warm autoimmune hemolytic anemia?