Inflammatory Bowel Disease

A 28-year-old woman from Delhi presents with a 6-month history of bloody diarrhea, abdominal cramping, and weight loss of 4 kg. She reports 6–8 bowel movements daily with blood and mucus. On examination, she is afebrile, abdomen is soft with mild left lower quadrant tenderness. Laboratory findings: hemoglobin 9.2 g/dL, ESR 68 mm/hr, CRP 12 mg/dL, fecal calprotectin 420 μg/g (normal <50). Colonoscopy reveals continuous mucosal inflammation with friability and loss of haustra, limited to the colon. Histopathology shows crypt distortion, increased chronic inflammation in the lamina propria, and absence of granulomas. What is the most likely diagnosis?

A 28-year-old man presents with a 6-week history of bloody diarrhea, abdominal cramping, and urgency. Colonoscopy reveals continuous mucosal inflammation limited to the colon with crypt distortion and surface ulceration. Histology confirms acute and chronic inflammation. He is diagnosed with ulcerative colitis and is now being initiated on induction therapy. What is the drug of choice for inducing remission in this patient?

A 28-year-old woman presents with a 6-month history of bloody diarrhea, abdominal cramping, and weight loss. Clinical examination reveals mild abdominal tenderness. Inflammatory markers (CRP and ESR) are elevated. Which investigation is most specific for confirming the diagnosis of ulcerative colitis?

A 35-year-old man with known Crohn's disease presents with fever, right lower quadrant pain, and a palpable mass. Laboratory tests show elevated inflammatory markers. Abdominal examination suggests a possible fistula. Which investigation is most appropriate to confirm the presence of an enterocutaneous fistula and assess its anatomy?

A 32-year-old man with a 6-year history of ulcerative colitis presents with bloody diarrhea and abdominal cramping. Colonoscopy reveals continuous mucosal inflammation with crypt abscesses and ulceration. Which is the most common site of involvement in ulcerative colitis?