Lymphomas

A 25-year-old male presents with painless cervical lymphadenopathy and B symptoms (fever, night sweats, weight loss). A lymph node biopsy reveals large, binucleated cells with prominent eosinophilic nucleoli, often described as an 'owl's eye' appearance, surrounded by a mixed inflammatory infiltrate. Which of the following is the most likely diagnosis?

A 7-year-old child from Africa presents with a rapidly growing jaw mass. A biopsy reveals a monotonous proliferation of medium-sized lymphoid cells with round nuclei, prominent nucleoli, and basophilic cytoplasm containing numerous small vacuoles. Macrophages with abundant clear cytoplasm are scattered throughout, creating a 'starry sky' appearance. Which genetic abnormality is most commonly associated with this condition?

A 55-year-old male presents with generalized lymphadenopathy, splenomegaly, and peripheral lymphocytosis. A lymph node biopsy shows a diffuse effacement of the normal architecture by a monotonous population of small to medium-sized lymphocytes with irregular nuclear contours. Immunohistochemistry is positive for CD5, CD20, CD23 negative, and cyclin D1. Which of the following translocations is most likely to be found?

Which of the following statements regarding Diffuse Large B-cell Lymphoma (DLBCL) is TRUE?

A 60-year-old patient undergoes a lymph node biopsy for generalized lymphadenopathy. Histopathology shows a nodular growth pattern composed of small cleaved and non-cleaved lymphocytes. Immunohistochemistry reveals CD20+, CD10+, BCL2+, and BCL6+. Cytogenetic analysis is most likely to reveal which of the following translocations?