Pulmonary Embolism

What is the most common source of pulmonary embolism in clinical practice?

Which of the following is the most common source of pulmonary embolism in clinical practice?

A 52-year-old woman from Mumbai presents with sudden onset dyspnea, syncope, and chest discomfort. She has a 3-week history of immobility following a femoral fracture. On examination: BP 80/50 mmHg, HR 128/min, RR 32/min, JVD prominent, right ventricular heave palpable. ECG shows sinus tachycardia with right axis deviation and T-wave inversion in V1–V3. Troponin I is elevated. Echocardiography reveals severe right ventricular dilatation with D-shaped septum and elevated RV pressure. CTPA confirms massive pulmonary embolism. Which pathological process in the pulmonary vasculature is responsible for the acute right ventricular failure observed in this patient?

A 58-year-old man with acute onset dyspnea and pleuritic chest pain is diagnosed with acute pulmonary embolism on CT pulmonary angiography. He has no contraindications to anticoagulation. What is the drug of choice for initial anticoagulation in this patient?

A 62-year-old woman with acute PE and hemodynamic instability (systolic BP 85 mmHg, RV dysfunction on echo) is admitted to the ICU. She has no absolute contraindications to thrombolysis. What is the drug of choice for immediate thrombolytic therapy?