Sickle Cell Disease

Which organ complication is most commonly responsible for mortality in adult patients with sickle cell disease?

Which of the following is the primary mechanism of hemolysis in sickle cell disease?

What is the molecular basis of sickle cell disease?

A 3-year-old child with known sickle cell disease presents with sudden onset of severe bone pain, fever, and elevated reticulocyte count. The clinical team suspects acute vaso-occlusive crisis with possible osteomyelitis. Which investigation would be most appropriate to differentiate between bone infarction and osteomyelitis?

A 6-year-old boy of African descent presents with acute chest pain, fever, and shortness of breath. Clinical examination reveals hepatosplenomegaly and bone tenderness. A peripheral blood smear shows sickle-shaped RBCs. Which investigation is most appropriate to confirm the diagnosis of sickle cell disease?