Thyroiditis

A 32-year-old woman presents with acute onset severe thyroid pain, fever, and dysphagia 2 weeks after an upper respiratory tract infection. Thyroid function tests show suppressed TSH and elevated free T4. All of the following are consistent with acute (suppurative) thyroiditis EXCEPT:

Which autoimmune antibody is most specific for Hashimoto's thyroiditis and correlates with disease activity?

A 38-year-old woman presents with a 2-week history of severe neck pain, fever, and malaise. She reports a recent upper respiratory tract infection 3 weeks ago. On examination, the thyroid gland is tender, firm, and enlarged. Laboratory investigations show TSH 0.2 mIU/L (normal 0.5–5.0), free T4 8.5 ng/dL (normal 0.8–1.8), elevated ESR 68 mm/hr, and negative thyroid peroxidase (TPO) and thyroglobulin antibodies. Thyroid ultrasound shows heterogeneous echotexture with reduced vascularity. What is the most likely diagnosis?

A 52-year-old woman from rural Maharashtra presents with a 6-month history of progressive neck swelling, dysphagia, and voice hoarseness. On examination, the thyroid is hard, fixed, and non-tender. Laboratory tests show TSH 8.2 mIU/L, free T4 0.6 ng/dL, negative TPO antibodies, and normal thyroglobulin. Thyroid ultrasound reveals diffuse heterogeneous echotexture with fibrosis extending into the anterior mediastinum. A fine-needle aspiration cytology (FNAC) shows fibrous tissue with sparse lymphocytes and no malignancy. What is the most likely diagnosis?

A 35-year-old woman presents with acute onset severe thyroid pain, fever, and malaise following an upper respiratory tract infection. Laboratory investigations show elevated ESR, normal thyroid function tests, and a low radioiodine uptake on thyroid scan. What is the drug of choice for this condition?