MAO Inhibitors

A 45-year-old patient is prescribed phenelzine for treatment-resistant depression. Which of the following best describes the mechanism of action of phenelzine?

A 32-year-old female presents with symptoms of atypical depression, including hypersomnia, hyperphagia, leaden paralysis, and rejection sensitivity. She has failed trials of two different SSRIs and venlafaxine. Which of the following antidepressant classes would be a reasonable next step, considering its particular efficacy in atypical depression?

Which of the following MAO inhibitors is characterized by its reversible and selective inhibition of MAO-A, leading to a lower risk of tyramine-induced hypertensive crisis compared to older, irreversible MAOIs?

A 58-year-old male on tranylcypromine for atypical depression presents to the emergency department with a severe headache, palpitations, and elevated blood pressure (200/110 mmHg) after consuming a large amount of aged cheese and red wine at a party. Which of the following is the most likely cause of his symptoms?

A patient with major depressive disorder is currently taking phenelzine. The psychiatrist is considering adding fluoxetine due to inadequate response. What is the most significant risk associated with combining these two medications, and what is the recommended management strategy?