Thyroid and Antithyroid Drugs

A 32-year-old woman with Graves' disease is started on propylthiouracil (PTU) therapy. After 6 weeks of treatment, she develops fever, sore throat, and a petechial rash. Her WBC count is 2,100/μL with severe neutropenia. Which investigation is most appropriate to confirm the suspected drug-induced complication?

A 28-year-old woman with Graves' disease is 8 weeks pregnant and requires antithyroid therapy. Regarding drug selection and adverse effects of antithyroid agents, all of the following are true EXCEPT:

A 28-year-old woman with newly diagnosed Graves' disease is counseled about antithyroid therapy. She is planning pregnancy within 6 months and has no history of drug allergies. Which antithyroid drug is the preferred first-line choice for her?

A 38-year-old woman with Graves' disease is treated with antithyroid drugs. She develops a rash and mild fever on day 5 of therapy. Which feature best distinguishes an allergic reaction to methimazole from one to PTU?

Methimazole is contraindicated in the first trimester of pregnancy because it is associated with which rare congenital syndrome?