A 52-year-old man with a 20-year history of alcohol use disorder presents with acute onset epigastric pain radiating to the back. Serum lipase is 8× ULN. CT abdomen shows pancreatic edema and peripancreatic fat stranding. Histopathology of a peripancreatic biopsy reveals the structure marked A — chalky-white deposits within adipose tissue. Which of the following best explains the pathophysiologic mechanism underlying this finding?

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