Those drugs which are secreted in bile do not require dose reduction in renal disease. Doxycycline is secreted in bile, so it is safe in renal failure Drugs (commonly asked) safe in renal diseases include: Safe (Cef): Cefoperazone, Ceftriaxone In The: Tigecycline R: Rifampicin E: Erythromycin N: Nafcillin A: Ampicillin L: Lincosamides (Clindamycin) Disease: Doxycycline
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