A 14-year-old girl with a history of unilateral retinoblastoma treated with radiotherapy 8 years ago now presents with severe pain and swelling in the proximal humerus. Imaging reveals a mixed lytic and sclerotic lesion with periosteal new bone formation. Biopsy shows malignant spindle cells with prominent osteoid production and mitotic figures. Which of the following genetic alterations is most likely responsible for the development of this tumour?

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