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    Subjects/Pathology/COPD — Emphysema and Chronic Bronchitis
    COPD — Emphysema and Chronic Bronchitis
    medium
    microscope Pathology

    A 62-year-old male smoker presents with progressive dyspnea and cough. Spirometry shows FEV₁/FVC ratio of 0.65. High-resolution CT chest reveals extensive destruction of distal alveoli with minimal bronchial wall thickening. Which single feature best distinguishes this patient's condition from chronic bronchitis?

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