A 65-year-old man presents with rapidly enlarging cervical lymphadenopathy, fever, and night sweats. Excisional lymph node biopsy shows sheets of large atypical cells with diffuse architectural effacement, vesicular nuclei, and prominent nucleoli. Immunohistochemistry reveals the immunoprofile marked D in the diagram. Which of the following statements best reflects the diagnostic and therapeutic significance of this immunoprofile in Diffuse Large B-Cell Lymphoma?

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