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    Subjects/Microbiology/Drug Resistance in TB — MDR, XDR
    Drug Resistance in TB — MDR, XDR
    hard
    bug Microbiology

    A 48-year-old woman from Mumbai with a history of MDR-TB (resistant to isoniazid and rifampicin) completed 20 months of second-line anti-TB therapy 6 months ago. She now presents with persistent cough and fever for 2 months. Repeat sputum smear microscopy is positive. Gene Xpert MTB/RIF confirms MTB with RIF resistance. Subsequent drug susceptibility testing (DST) shows resistance to isoniazid, rifampicin, levofloxacin, and amikacin. What is the most likely diagnosis?

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