A 35-year-old man from Mumbai is found to have HBsAg positive on routine screening. Further serological testing shows: HBsAg (+), anti-HBs (−), HBeAg (+), anti-HBe (−), anti-HBc IgM (−), anti-HBc IgG (+). Which single marker best distinguishes acute HBV infection from chronic HBV infection in this patient?

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