Which of the following HPV types is most commonly associated with cervical cancer?

Explanation

## HPV Classification and Oncogenic Potential **Key Point:** HPV types are classified as low-risk and high-risk based on their association with malignancy. ### High-Risk (Oncogenic) HPV Types HPV-16 and HPV-18 are the most oncogenic types, responsible for approximately 70% of cervical cancers worldwide. HPV-16 alone accounts for ~50% of cervical cancer cases. ### Other High-Risk Types HPV-31, HPV-33, HPV-35, HPV-39, HPV-45, HPV-51, HPV-52, HPV-56, HPV-58, HPV-59, and HPV-66 are also high-risk but less frequently associated with cervical cancer than HPV-16 and HPV-18. ### Low-Risk (Non-Oncogenic) Types | HPV Type | Association | Clinical Manifestation | |----------|-------------|------------------------| | HPV-6, HPV-11 | Low-risk | Benign genital warts, recurrent respiratory papillomatosis | | HPV-1, HPV-2 | Low-risk | Common and plantar warts | **High-Yield:** HPV-16 and HPV-18 together account for >70% of cervical cancers; HPV-16 is the most oncogenic single type. **Clinical Pearl:** Quadrivalent and nonavalent vaccines target HPV-16 and HPV-18 (plus additional types in nonavalent), which is why vaccination is so effective at preventing cervical cancer.