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    Subjects/Biochemistry/Lysosomal Storage Disorders
    Lysosomal Storage Disorders
    medium
    flask-conical Biochemistry

    A 3-year-old boy from rural Maharashtra presents with progressive hepatosplenomegaly, developmental delay, and recurrent respiratory infections over the past 18 months. On examination, he has coarse facial features, corneal clouding, and a palpable liver edge 4 cm below the costal margin. Bone X-rays show dysostosis multiplex. Serum enzyme assays reveal markedly elevated acid phosphatase and arylsulfatase levels. A bone marrow smear shows foamy macrophages with zebra-body inclusions on electron microscopy. What is the most likely diagnosis?

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