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    Subjects/Biochemistry/Lysosomal Storage Disorders
    Lysosomal Storage Disorders
    medium
    flask-conical Biochemistry

    A 3-year-old boy from rural Maharashtra presents with progressive developmental delay, hepatosplenomegaly, and recurrent respiratory infections over the past 18 months. On examination, he has coarse facial features, corneal clouding, and a palpable spleen 4 cm below the costal margin. Bone marrow aspirate shows foamy macrophages. Urine shows elevated heparan sulfate and dermatan sulfate. Which of the following lysosomal storage disorders is most likely?

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