A 52-year-old man with chronic pain from metastatic cancer is on morphine 60 mg daily. He presents to the emergency department with severe respiratory depression (RR 8/min, SpO₂ 82%), pinpoint pupils, and altered mental status. His wife reports he accidentally took a double dose 2 hours ago. Blood pressure is 88/54 mmHg, and he is unresponsive to verbal stimuli. What is the most appropriate immediate pharmacological intervention?

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