A 35-year-old woman undergoes cervical cytology screening as part of routine health check-up. On Pap smear examination, the pathologist identifies cells with a characteristic perinuclear halo, shrunken hyperchromatic nuclei, and binucleation. The structure marked **D** in the diagram represents the cytopathic effect responsible for these findings. Which of the following best describes the clinical significance of identifying this finding on cervical cytology?