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Subjects/Pharmacology/Pharmacology
Pharmacology
medium
pill Pharmacology

Which of the following drugs is a P-glycoprotein inducer?

A. Azithromycin
B. Ketoconazole
C. Itraconazole
D. Rifampicin

Explanation

Answer- D. RifampicinRifampicin induces the isoenqymes CYP3A4, 2C8, 2C9, 2CI9, 286, and the transpoer P-glycoprotein. When coadministeredwith drugs that are substrates of the same enzymes, their metabolism may be accelerated resulting in lowerconcentration and less efficacy.Inducer-AmprenavirClotrimazoleDexamethasoneIndinavirMorphineNelfinavirPhenothiazineRetinoic acidRifampinRitonavirSaquinavirSt John's wo

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