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Subjects/Pharmacology/Pharmacology
Pharmacology
medium
pill Pharmacology

Ganglionic transmission is mediated by:

A. Presynaptic alpha-receptors
B. Postsynaptic beta-receptors
C. Postsynaptic dopaminergic receptors
D. Postsynaptic nicotinic receptors

Explanation

Ans: D .Postsynaptic nicotinic receptors(Ref: Goodman Gilman 13/e p108, 12Ie p255; Katzung 13Ie p108, 12/e p98).Ganglionic transmission is mediated by nicotinic receptors present post-synaptically.Nicotinic acetylcholine (ACh) receptor mediates neurotransmission post-synaptically at the neuromuscular junction and peripheral autonomic ganglia.In CNS, controls release of neurotransmitters from presynaptic sites.The receptor is called the nicotinic acetylcholine receptor - Due to both alkaloid nicotine & neurotransmitter ACh can stimulate the receptor.

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