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Subjects/Pharmacology/Pharmacology
Pharmacology
medium
pill Pharmacology

Which of the following diuretic can be given in mild to moderate hypeension?

A. Potassium sparing diuretic
B. Osmotic diuretic
C. Thiazide diuretic
D. Loop diuretic

Explanation

Ans: C. Thiazide diureticThiazide diuretics :Given in mild to moderate hypeension.Low-dose thiazide diuretics used alone or in combination with other antihypeensive drugs.Safe, efficacious, inexpensive & reduce clinical events. MOA:Inhibits Na/Cl- pump in DCT a Increases sodium excretion.In long term - Acts as vasodilators.Provide additive blood pressure-lowering effects (On combination with beta blockers, ACE-I, ARBs).Drug of Choicein HypeensionConditionDrug of ChoiceHypeensionThiazidesHypeension with BPHPrazosinHypeension with diabetes mellitusACE inhibitorsHypeension with ischemic hea disease (angina)Beta-blockersHypeension with chronic kidney diseaseACE inhibitorsHypeension in pregnancyAlpha-methyldopaHypeensive emergenciesNicardipine + EsmololHypeensive emergencies in cheese reactionPhentolamineHypeensive emergencies in clonidine withdrawalPhentolamineHypeensive emergencies in aoic dissectionNitroprusside + EsmololHypeensive emergencies in pregnancyLabetalol(Ref: Harrison 19/e p1623).

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