Which of the following is not true for rifabutin as compared to rifampicin?

Question

Accepted Answer

D. Rifabutin is more efficacious for pulmonary TB as compared to rifampicin. Ans: D. Rifabutin is more efficacious for pulmonary TB as compared to rifampicin(Ref Goodman Gilman 12/e p1550, 1552, 1554, 1568; Katzung 12/e p845)Rifabutin:Stronger activity against Mycobacterium avium complex (compared to rifampicin).Ineffective against Mycobacterium tuberculosis. RifabutinRifampicin (Rifampin)RifapentineProtein binding 718597Oral 2068deg-tmax (hours)2.5-4.01.5-2.05.0-6.0degHalf-life (hours)32-67deg2-5deg14-18Intracellular/extracellular9524-60degAutoinduction40%deg38%20%CYP3A inductionWeakPronouncedModerateCYP3A substrateYesdegNoNo

Answer

A. Rifabutin has the longer half-life than rifampicin

Answer

B. Rifabutin has lesser incidence of drug-interactions

Answer

C. Rifabutin is more efficacious against MAC as compared to rifampicin

Which of the following is not true for rifabutin as compared to rifampicin?

Explanation

Practice similar questions

Which of the following is not true for rifabutin as compared to rifampicin?

Explanation

Practice similar questions