Ans. B. DinoprostonePostpaum hemorrhage, the loss of more than 500 mL of blood after delivery, occurs in up to 18 percent of bihs and is the most common maternal morbidity in developed countries. Dinoprostone:Naturally occurring prostaglandin E2 (PGE2). It has impoant effects in labour.It also stimulates osteoblasts to release factors which stimulates bone resorption by osteoclasts.As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour. Indication:For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed aboion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period.In the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpaum hemorrhage.
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