Streptomycin (antitubercular) causes vestibular damage on prolonged use. Adverse effects This class of drugs is notorious for their adverse effects like ototoxicity and nephrotoxicity. About 1/5th patients given streptomycin 1 gm BD i.m. experience vestibular disturbances although auditory disturbances are less common. Streptomycin has the lowest nephrotoxicity among aminoglycosides; probably because it is not concentrated in the renal cortex. Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 94,798
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