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Subjects/Pharmacology/Pharmacology
Pharmacology
medium
pill Pharmacology

Which of the following drugs can be given in renal failure safely?

A. Saxagliptin
B. Linagliptin
C. Vildagliptin
D. Sitagliptin

Explanation

Ans: B. Linagliptin(Ref Goodman Gilman 12/e p1264; Katzung 13/e p740, 12/e p761; FDA website: http://wwwfda.gov/ Safety/ MedWatch/Safetylnformation/ircm3 I 9215.htm)Linagliptin:Given safely in renal failure.Chronic kidney disease:Major complication in type 2 diabetes.Metformin usage is challenging.More severe renal disease - Less likely for metformin use.Due to safety concerns.

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