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Subjects/Pharmacology/Pharmacology
Pharmacology
medium
pill Pharmacology

Which one of the following is a gender-specific side-effect of valproate?

A. Polycystic ovarian syndrome
B. Alopecia
C. Weight loss
D. Tremor

Explanation

Ans: A. Polycystic ovarian syndrome Side-effects of Valproic AcidMC side effects are transient GI symptoms (anorexia, nausea & vomiting)Effects on the CNS: Sedation, ataxia & Rash, alopecia Stimulation of appetite & weight gain.Increase the chance of polycystic ovary syndrome (PCOS) in women with epilepsy or bipolar disorders Elevation of hepatic transaminases, microvesicular steatosisAcute pancreatitisHyperammonemiaNeural tube defects

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