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Subjects/Pharmacology/Pharmacology
Pharmacology
medium
pill Pharmacology

Ritonavir inhibits metabolism of all of the following drugs except:

A. Amiodarone
B. Phenytoin
C. Cisapride
D. Midazolam

Explanation

Ans. b. Phenytoin (Ref Goodman Gillman Ilth/1302; Katzung II/e plI44)Ritonavir inhibits metabolism of Amiodarone, Cisaprlde, Midazolam and but not the phenytoin'The majority (95%o) of phenytoin is metabolized principalty in the hepatic endoplasmic reticulum by CYP2C9/10 and to a lesser extent CYP2C9.'

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