A 72-year-old man from Delhi undergoes prostate biopsy for elevated PSA (18 ng/mL) and hard nodule on DRE. Histopathology shows glandular structures with cribriform pattern, nuclear enlargement, and prominent nucleoli. Gleason score is assigned as 4 + 4 = 8. Which of the following best describes the pathological significance of this Gleason score?

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