A 32-year-old Indian woman presents with bilateral hilar lymphadenopathy on chest X-ray, dry cough, and erythema nodosum. Transbronchial biopsy of a mediastinal lymph node shows granulomatous inflammation. The structure marked C in the diagram (multinucleated giant cell with asteroid body) is characteristic of the histopathological findings. Which of the following best distinguishes this finding from tuberculosis?

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