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    Subjects/Medicine/Sarcoidosis with Bilateral Hilar Lymphadenopathy (Stage I-II)
    Sarcoidosis with Bilateral Hilar Lymphadenopathy (Stage I-II)
    medium
    stethoscope Medicine

    A 32-year-old African-American woman presents with a 6-week history of dry cough, exertional dyspnea, and fatigue. She has tender erythematous nodules on both shins, arthralgias affecting the ankles, and anterior uveitis on slit-lamp examination. Chest radiograph shows the classic "1-2-3 sign" with right paratracheal lymphadenopathy and symmetric bilateral hilar lymphadenopathy. The structure marked **C** (left hilar lymphadenopathy) is part of the radiographic hallmark that defines which Scadding stage of pulmonary sarcoidosis?

    A. Stage IV: Pulmonary fibrosis with hilar lymphadenopathy regression
    B. Stage II: Bilateral hilar lymphadenopathy with parenchymal infiltrates
    C. Stage III: Parenchymal infiltrates without hilar lymphadenopathy
    D. Stage I: Bilateral hilar lymphadenopathy without parenchymal involvement

    Explanation

    Why Stage I is right

    The radiographic hallmark that defines Scadding Stage I pulmonary sarcoidosis is symmetric bilateral hilar lymphadenopathy without parenchymal involvement. The structure marked C (left hilar lymphadenopathy), together with right hilar lymphadenopathy (B) and right paratracheal lymphadenopathy (A), forms the classic "1-2-3 sign" or Garland triad. The presence of clear lung fields (D) confirms the absence of parenchymal disease, placing this patient in Stage I. This constellation of findings—bilateral hilar lymphadenopathy with clear lungs—is the defining radiographic criterion for Stage I, regardless of extrapulmonary manifestations such as erythema nodosum or uveitis (Lofgren syndrome).

    Why each distractor is wrong

    • Stage II: While Stage II does include bilateral hilar lymphadenopathy, it is distinguished by the addition of parenchymal infiltrates (reticular or nodular opacities). This patient's lung fields are clear, excluding Stage II.
    • Stage III: Stage III features parenchymal infiltrates without hilar lymphadenopathy. This patient has prominent bilateral hilar lymphadenopathy, which rules out Stage III.
    • Stage IV: Stage IV represents end-stage pulmonary fibrosis with regression of hilar lymphadenopathy. This patient has active, prominent bilateral hilar lymphadenopathy, not fibrosis or lymph node regression.
    High-YieldNEET PG
    Scadding Stage I = bilateral hilar lymphadenopathy + clear lungs; the presence of C (left hilar node) is essential to the Stage I diagnosis.

    Harrison's Principles of Internal Medicine, 21st Edition, Chapter 360: Sarcoidosis

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