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    Subjects/Biochemistry/Second Messengers — cAMP, IP3, DAG
    Second Messengers — cAMP, IP3, DAG
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    flask-conical Biochemistry

    A 52-year-old man with a history of polydipsia and polyuria is suspected of having nephrogenic diabetes insipidus (NDI) due to lithium use. To confirm that the kidney's collecting duct cells are insensitive to vasopressin (ADH) and cannot generate the cAMP second messenger response, which investigation is most appropriate?

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