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    Subjects/Medicine/Supraventricular Tachycardias
    Supraventricular Tachycardias
    medium
    stethoscope Medicine

    A 28-year-old woman presents to the emergency department with palpitations and chest discomfort lasting 2 hours. She reports sudden onset while sitting at her desk. Vital signs: HR 180 bpm, BP 110/70 mmHg, RR 18/min. Physical examination reveals no murmurs or signs of heart failure. 12-lead ECG shows a narrow complex tachycardia with a rate of 180 bpm; P waves are buried in the T wave of the preceding beat. Carotid sinus massage produces no change in the rhythm. An adenosine IV bolus (6 mg) is administered, resulting in transient AV block and sudden termination of the tachycardia, followed by normal sinus rhythm. What is the most likely diagnosis?

    A. Atrioventricular reentrant tachycardia (AVRT) due to an accessory pathway
    B. Atrioventricular nodal reentrant tachycardia (AVNRT)
    C. Atrial flutter with 1:1 conduction
    D. Sinus tachycardia with anxiety

    Explanation

    ## Diagnosis: Atrioventricular Nodal Reentrant Tachycardia (AVNRT) ### Clinical Presentation A young woman with sudden-onset palpitations, a narrow complex tachycardia at 180 bpm, and no structural heart disease is a classic presentation of AVNRT — the **most common** paroxysmal SVT in adults, particularly young women. ### Key ECG Findings **Key Point:** In AVNRT, the reentrant circuit is entirely (or nearly entirely) within the AV node, using a slow pathway (antegrade) and a fast pathway (retrograde). Because retrograde atrial activation occurs almost simultaneously with ventricular activation, **P waves are buried within or at the very end of the QRS/T wave** — producing the characteristic "pseudo-R'" in V1 or "pseudo-S" in inferior leads. This is the hallmark of **typical (slow-fast) AVNRT**. In AVRT (accessory pathway–mediated), retrograde conduction via the accessory pathway takes slightly longer, so P waves typically appear **just after** the QRS (in the ST segment), giving a short but **measurable** RP interval (RP < 70–80 ms in AVNRT vs. RP > 70 ms in AVRT). The stem describes P waves "buried in the T wave of the preceding beat," which is most consistent with AVNRT. ### Why Not AVRT? **High-Yield:** AVRT requires an accessory pathway (e.g., WPW syndrome or a concealed pathway). In orthodromic AVRT, retrograde conduction via the accessory pathway produces a P wave that is visible **after** the QRS in the ST segment — not buried within the T wave. Additionally, there is no mention of a delta wave on baseline ECG, pre-excitation, or prior WPW diagnosis. While AVRT can also terminate with adenosine, the P-wave timing described is more consistent with AVNRT. ### Mechanism of Termination **High-Yield:** Adenosine causes transient AV nodal block, interrupting the reentrant circuit (which depends entirely on AV nodal tissue in AVNRT). This results in abrupt termination and restoration of sinus rhythm — a classic response confirming AV nodal dependence of the tachycardia. ### Differential Features | Feature | AVNRT | AVRT | Atrial Flutter | |---------|-------|------|----------------| | **P wave timing** | Buried in QRS/T wave (RP < 70 ms) | Just after QRS in ST segment (RP 70–150 ms) | Saw-tooth, visible between QRS | | **Rate** | 140–250 bpm | 140–250 bpm | 250–350 bpm atrial | | **Adenosine response** | Abrupt termination | Abrupt termination | Slows AV conduction, reveals flutter waves | | **Accessory pathway** | No | Yes (WPW or concealed) | No | | **Most common in** | Young women | Younger patients, WPW | Older, structural disease | **Clinical Pearl:** The single most important distinguishing feature between AVNRT and AVRT on ECG is the **RP interval**: AVNRT has RP < 70 ms (P buried in QRS/T), while orthodromic AVRT has RP > 70 ms (P visible in ST segment). Definitive diagnosis requires electrophysiology study (EPS). ### Why Other Options Are Wrong - **AVRT (A):** Requires accessory pathway; P waves appear after QRS in ST segment, not buried in T wave; no delta wave or WPW history mentioned. - **Atrial flutter with 1:1 (C):** Atrial rate 250–350 bpm; saw-tooth flutter waves; 1:1 conduction is rare and usually seen with accessory pathways or sympathomimetics. - **Sinus tachycardia (D):** Gradual onset/offset; P waves precede QRS; rate rarely exceeds 150–160 bpm; adenosine would not terminate it abruptly. [cite: Harrison's Principles of Internal Medicine, 21e, Ch. 226; Braunwald's Heart Disease, 12e]

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