DIC

Which of the following clinical conditions is the MOST common cause of DIC in hospitalized patients in India?

A 38-year-old woman with acute promyelocytic leukemia (APL) presents with fever, bleeding gums, and petechiae. Laboratory findings show platelet count 45,000/μL, PT 18 seconds (control 12), aPTT 42 seconds (control 36), and fibrinogen 95 mg/dL. Which investigation is most specific for confirming disseminated intravascular coagulation (DIC) in this patient?

A 52-year-old man with sepsis secondary to gram-negative bacteremia develops DIC with severe thrombocytopenia (platelets 15,000/μL), prolonged PT/aPTT, and fibrinogen 120 mg/dL. After aggressive fluid resuscitation and broad-spectrum antibiotics, his coagulopathy persists. Which anticoagulant is the drug of choice for DIC in this setting?

In disseminated intravascular coagulation, which of the following laboratory findings is MOST specific for active fibrinolysis and distinguishes DIC from other causes of thrombocytopenia?

A 42-year-old man with sepsis secondary to gram-negative bacteremia develops acute onset petechiae, bleeding from gums, and hemoptysis. Coagulation profile shows: platelet 28,000/μL, fibrinogen 110 mg/dL, PT 22 seconds, aPTT 48 seconds, D-dimer >10 μg/mL (normal <0.5). Which investigation would be most useful to differentiate DIC from primary fibrinolysis in this patient?