Platelet Disorders

A 32-year-old woman from Delhi presents with a 3-month history of easy bruising, petechiae on her lower extremities, and menorrhagia. She denies fever, lymphadenopathy, or hepatosplenomegaly. Laboratory investigations show: Hemoglobin 10.2 g/dL, WBC 7,200/μL, platelet count 18,000/μL, PT 12 s, aPTT 32 s, fibrinogen 280 mg/dL. Bone marrow examination reveals normal cellularity with increased megakaryocytes. Peripheral blood smear shows no schistocytes or abnormal cells. What is the most likely diagnosis?

Which of the following is the primary structural defect in Bernard-Soulier syndrome?

A 58-year-old man with a 10-year history of essential hypertension presents to the emergency department with sudden-onset severe headache, confusion, and blurred vision. His blood pressure is 210/140 mmHg. Laboratory investigations reveal: Hemoglobin 9.8 g/dL, platelet count 45,000/μL, creatinine 2.8 mg/dL (baseline 1.0), LDH 680 U/L, haptoglobin <10 mg/dL, reticulocyte count 8%, PT 13 s, aPTT 34 s, fibrinogen 320 mg/dL. Peripheral blood smear shows numerous schistocytes and polychromasia. What is the most likely diagnosis?