Syphilis — Clinical Stages

A 35-year-old woman presents with a maculopapular rash involving the trunk and extremities, generalized lymphadenopathy, and condyloma lata in the anogenital region. She reports a history of a painless ulcer 8 weeks ago that healed spontaneously. Which investigation is most appropriate to confirm secondary syphilis?

A 35-year-old woman with a 2-year history of untreated syphilis now presents with aortic regurgitation, aortitis, and a positive RPR. Serological tests confirm secondary syphilis progressing to tertiary (cardiovascular) syphilis. What is the drug of choice for treatment of tertiary cardiovascular syphilis?

A 32-year-old woman from Mumbai presents with a maculopapular rash on the trunk and extremities, including the palms and soles. She also has condyloma lata in the perianal region, mucous patches in the mouth, and generalized lymphadenopathy. Serological tests show high-titre RPR and positive FTA-ABS. Which is the most common systemic manifestation of secondary syphilis?

A 28-year-old man presents with a painless, indurated ulcer on the glans penis with a clean base and raised borders. Regional lymph nodes are enlarged, non-tender, and mobile. Dark-field microscopy of the ulcer exudate reveals motile spirochetes. Which is the most common site of the primary chancre in males?

A 35-year-old woman from Mumbai presents with a maculopapular rash involving the trunk and extremities (including palms and soles) for 2 weeks. She also reports fever, generalized lymphadenopathy, and a history of a painless genital ulcer that healed spontaneously 8 weeks ago. RPR titre is 1:64 (positive). FTA-ABS is positive. What is the most appropriate next step in management?