Warts — HPV

A 28-year-old woman presents with multiple flesh-coloured, dome-shaped papules on her hands and feet that have been present for 6 months. She reports that her 5-year-old daughter has similar lesions. On examination, the lesions are firm, well-demarcated, and show a characteristic "mosaic" pattern on the plantar surface. The patient is otherwise healthy with no immunosuppression. Which HPV type is most likely responsible for these lesions?

A 35-year-old man with HIV infection (CD4 count 150 cells/μL) presents with extensive, rapidly progressive warts on his hands, feet, and genitalia. The lesions are hyperkeratotic, verrucous, and some show signs of malignant transformation with irregular borders and bleeding. Biopsy of a genital lesion shows koilocytosis and mild dysplasia. Which HPV type is most likely to be found in this patient, and what is the primary concern?

A 28-year-old woman presents with multiple painful lesions on her vulva and perianal region for 3 weeks. She reports severe pain during micturition and defecation. On examination, she has grouped vesicles on an erythematous base, along with several flesh-coloured, dome-shaped papules with a rough surface on the labia majora and perianal skin. She is sexually active with a new partner 2 months ago. What is the most likely diagnosis of the dome-shaped papules?

A 42-year-old man with a history of renal transplantation 8 years ago presents with multiple warty lesions on his hands, feet, and genitalia that have progressively worsened over the past 2 years despite multiple treatment attempts (cryotherapy, topical salicylic acid). He is on tacrolimus and mycophenolate mofetil for immunosuppression. Histopathology of a lesion shows koilocytosis and hyperkeratosis. Which HPV type is most likely responsible, and what is the primary concern in this patient?