A 35-year-old man presents with a 2-year history of painless, foul-smelling otorrhea from the right ear that has not responded to multiple courses of topical antibiotics. Audiometry shows air-bone gap of 25 dB with an additional 15 dB sensorineural component. High-resolution CT temporal bone reveals scutum erosion and long process of incus destruction. The audiometric pattern marked **A** in the diagram represents mixed hearing loss from cholesteatoma with ossicular erosion. Which of the following is the pathophysiological mechanism of bone erosion in this condition?
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