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    SubjectsENTCisplatin Ototoxicity — Post-Chemotherapy SNHL
    ClinicalENT

    Cisplatin Ototoxicity — Post-Chemotherapy SNHL

    1 MCQs in ENT for NEET PG

    1 Medium
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    A 9-year-old boy with high-risk hepatoblastoma is undergoing cisplatin-based chemotherapy (SIOPEL-4 protocol). After 4 cycles (cumulative dose 480 mg/m²), he reports difficulty hearing high-pitched sounds like birdsong and the doorbell. His teacher notes he misses classroom instructions. Otoscopy is normal; Weber test does not lateralize; Rinne test is positive bilaterally. Pure-tone audiometry reveals the pattern marked **C** in the diagram. Which of the following best explains the mechanism of the hearing loss pattern shown in **C**?

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