A 4-month-old girl born to non-consanguineous parents fails universal newborn hearing screening (absent OAE bilaterally). Audiometry confirms bilateral profound SNHL (>90 dB across all frequencies). Tympanometry is normal (type A). MRI temporal bones shows normal cochleovestibular anatomy. Genetic testing reveals a single heterozygous GJB2 mutation (35delG) and a large deletion del(GJB6-D13S1830) on the opposite chromosome. The audiological and genetic findings shown in the diagram at **A** are consistent with which of the following pathophysiological mechanisms?
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