A 62-year-old man with decompensated congestive heart failure and stage 4 chronic kidney disease receives high-dose intravenous furosemide (200 mg bolus followed by continuous infusion at 20 mg/hr) for acute pulmonary edema. Within 4 hours, he develops sudden bilateral hearing loss with aural fullness and high-pitched tinnitus. Bedside audiometry shows the pattern marked **A** in the diagram: bilateral symmetric moderate sensorineural hearing loss with flat audiometric contour across all frequencies (45–55 dB thresholds from 250 Hz to 8000 Hz), preserved speech discrimination, and markedly reduced otoacoustic emissions. Which of the following best explains the mechanism of hearing loss in this patient?
Ready to test yourself?
Test your ENT knowledge with AI-powered MCQs and detailed explanations — no signup required to try.
Sign up free and practice all 1 Loop Diuretic (Furosemide) Ototoxicity MCQs with AI-powered explanations tailored to your performance.
Create Free Account