A 16-year-old male athlete presents with 5 months of progressive deep aching pain in the left proximal tibia, worse at night and sometimes waking him from sleep. The pain is dramatically relieved within 20–30 minutes of taking ibuprofen. Examination reveals point tenderness over the proximal tibial diaphysis. Radiograph and CT imaging show the lesion marked **A** in the diagram: a small (8 mm) round cortical radiolucent nidus with a central focus of mineralization and surrounding dense reactive cortical thickening. Which of the following best explains the dramatic pain relief with NSAIDs in this patient?
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