A 4-month-old female infant presents with clusters of brief flexor spasms beginning 3 weeks ago. Neuroimaging reveals agenesis of the corpus callosum and pathognomonic chorioretinal lacunae around the optic disc. The EEG shows the pattern marked **A** in the diagram. Which of the following best explains the electrophysiological finding marked **A**?
A 4-month-old girl presents with clusters of infantile spasms (flexor spasms with head drops and arm extension) beginning at 10 weeks of life. She has profound developmental delay, poor visual fixation, and bilateral chorioretinal lacunae with optic nerve coloboma. MRI shows complete corpus callosum agenesis, bilateral polymicrogyria, and interhemispheric cyst. Video-EEG is obtained. The pattern marked **B** in the diagram—dissociated hemispheric activity with independent burst-suppression in each hemisphere—is observed. Which of the following best explains the pathophysiologic basis for this distinctive EEG pattern in Aicardi syndrome?
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