A 2-year-old girl presents with severe developmental delay, absent speech, and a characteristic happy demeanor with frequent unprovoked laughter. Her parents report jerky, puppet-like movements and she had her first seizure at age 18 months. The diagram shows chromosomal abnormalities associated with imprinting disorders. The structure marked **B** (maternal 15q11-q13 deletion) is identified on genetic testing. Which of the following best explains the molecular basis of her clinical features?
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